rs3918252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Zymographic MMP-2 and MMP-9 production, MMP-9 activity and invasion through matrigel in vitro were significantly less in sgk1(-/-) than in sgk1(+/+)macrophages and in control plasmid-transfected or inactive (K127N)SGK1-transfected than in constitutively active (S422D)SGK1-transfected THP-1 cells.
|
25614279 |
2015 |
rs9856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XIAP rs8371 and rs9856 polymorphisms were associated with tumor node metastasis (TNM) staging, depth of invasion and lymph node metastasis.
|
29037837 |
2017 |
rs8371
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XIAP rs8371 and rs9856 polymorphisms were associated with tumor node metastasis (TNM) staging, depth of invasion and lymph node metastasis.
|
29037837 |
2017 |
rs4579555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Women with the rs2289937 C genotype (CC+CT) of rs4570 and rs4579555 genotypes and haplotype 1 (TTTCAGGCGC) were significantly associated with CC risk, while women with low frequencies of haplotype 6 (TTTTAGGCGC) also increased the risk of CC.Rad21-specific shRNA decreased cancerous cell proliferation, migration, and invasion and increased the proportion of cells in G2/M phase as well as sensitivity to radiation.
|
29797792 |
2018 |
rs4570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Women with the rs2289937 C genotype (CC+CT) of rs4570 and rs4579555 genotypes and haplotype 1 (TTTCAGGCGC) were significantly associated with CC risk, while women with low frequencies of haplotype 6 (TTTTAGGCGC) also increased the risk of CC.Rad21-specific shRNA decreased cancerous cell proliferation, migration, and invasion and increased the proportion of cells in G2/M phase as well as sensitivity to radiation.
|
29797792 |
2018 |
rs2289937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Women with the rs2289937 C genotype (CC+CT) of rs4570 and rs4579555 genotypes and haplotype 1 (TTTCAGGCGC) were significantly associated with CC risk, while women with low frequencies of haplotype 6 (TTTTAGGCGC) also increased the risk of CC.Rad21-specific shRNA decreased cancerous cell proliferation, migration, and invasion and increased the proportion of cells in G2/M phase as well as sensitivity to radiation.
|
29797792 |
2018 |
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With the subgroup of EGFR L858R mutation, variant genotypes (GT + TT) of <i>eNOS</i> 894 G/T were significantly associated with lymph node invasion.
|
30026850 |
2018 |
rs11662595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that rs11662595 significantly decreased the ability of HRH4 to activate Gi protein, which resulted in facilitation of EMT progress, cell proliferation, and invasion behavior in vitro.
|
28847511 |
2017 |
rs1057519906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed here that C6 glioma cells transiently over-expressing IDH2(R172G) induced nuclear accumulation of β-catenin, up-regulation of HIF-1α signaling and corresponding proteins expression that were closely related with tumor invasion and chemo-resistance.
|
22309944 |
2012 |
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
rs751295137
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
rs760101437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
rs757786591
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion.
|
25795715 |
2015 |
rs771086543
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further showed that ARF6/extracellular signal-regulated kinase (ERK) signaling is required for the EFA6A-mediated cell invasion because both EFA6A(E242K) and ARF6 dominant negative mutant ARF6(T27N) markedly reduced the phosphorylated ERK level and EFA6A-mediated invasive capacity.
|
16452216 |
2006 |
rs772903705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We further showed that ARF6/extracellular signal-regulated kinase (ERK) signaling is required for the EFA6A-mediated cell invasion because both EFA6A(E242K) and ARF6 dominant negative mutant ARF6(T27N) markedly reduced the phosphorylated ERK level and EFA6A-mediated invasive capacity.
|
16452216 |
2006 |
rs35697691
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that in comparison with wild type ERK3, both L290P and L290V mutants have greatly increased activity in promoting cancer cell migration and invasion, but have little impact on ERK3's role in cell proliferation.
|
29101390 |
2017 |
rs28934578
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
rs751295137
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
rs760101437
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
rs1200003171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that forced over-expression of p53-R175H significantly promoted cell migration and invasion, and induced activation of the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/AKT pathway.
|
19917135 |
2009 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found significant association between BRAF (V600E) mutation and age (P < 0.0001), extrathyroidal invasion (P = 0.017), lymph node metastasis (P = 0.038) and TNM stage III/IV (P = 0.001).
|
27387551 |
2016 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found significant association between BRAF (V600E) mutation and age (P < 0.0001), extrathyroidal invasion (P = 0.017), lymph node metastasis (P = 0.038) and TNM stage III/IV (P = 0.001).
|
27387551 |
2016 |